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Friday, April 17, 2020 | History

2 edition of Modeling of Inhalation Exposure to Vapors found in the catalog.

Modeling of Inhalation Exposure to Vapors

Vera Fiserova-Bergerova

Modeling of Inhalation Exposure to Vapors

Uptake, Distribution, and Elimination

by Vera Fiserova-Bergerova

  • 98 Want to read
  • 29 Currently reading

Published by Crc Pr I Llc .
Written in English

    Subjects:
  • Mathematical models,
  • Medical toxicology,
  • Pharmacodynamics,
  • Toxicology,
  • Gases, Asphyxiating and poison,
  • Pharmacokinetics,
  • Physiological effect

  • The Physical Object
    FormatHardcover
    ID Numbers
    Open LibraryOL8260801M
    ISBN 100849363160
    ISBN 109780849363160

    Book Description. Exposure to Contaminants in Drinking Water: Estimating Uptake through the Skin and by Inhalation examines the current state of science in this field by identifying and reviewing the available information resources; evaluating various models and approaches; and demonstrating the feasibility of developing estimates of the distribution of absorbed doses of . () that compared inhalation and oral absorption in rats and mice. The authors found that during a 6-hour inhalation exposure, the retention of [ C]benzene decreased from 33 ± 6% to 15 ± 9% for rats and from 50 ± 1% to 10 ± 2% for mice as exposure concentration increased from 26 to 2, mg/m. 3 (10 to 1, ppm).File Size: KB. This chapter contains information on the toxic effects of exposure to the vapors of JP-5, JP-8, and DFM on the hematopoietic system in experimental animals. There is no information in the literature on these effects in humans. The toxic effects of vapors from petroleum-derived and shale-derived JP Inhalation is a major route of exposure that occurs when an individual breathes in polluted air which enters the respiratory tract. Identification of the pollutant uptake by the respiratory system can determine how the resulting exposure contributes to the this way, the mechanism of pollutant uptake by the respiratory system can be used to predict potential health impacts .

    fuel. If the Navy finds evidence that there is exposure or a potential for exposure to respirable aerosols of the fuels, modified guidelines for limiting such exposures will have to be developed because of concern that the toxicity is greater from the less-volatile fractions in aerosols than from the more-volatile fractions in vapors.


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Modeling of Inhalation Exposure to Vapors by Vera Fiserova-Bergerova Download PDF EPUB FB2

Modeling of Inhalation Exposure to Vapors: Uptake Distribution and Elimination, Vol. 2: Medicine & Health Science Books @ Modeling of Inhalation Exposure to Vapors: Uptake, Distribution, and Elimination. Volume I.

CRC Press, Ex-technical library hardback w/o dust jacket, minimal library marks, writing packed page edges, pages, text is clean & unmarked, good condition.

Modeling of inhalation exposure to vapors: uptake, distribution, and elimination. Modeling Of Inhalation Exposure To Typically, exposure occurs by one of three exposure routes—inhalation, ingestion, or dermal.

Inhalation exposure can result from breathing air that is contaminated with particulate matter (e.g., dust), vapors (e.g., volatile or semivolatile contaminants), or aerosols. Occupational inhalation exposure and systemic inhalation absorption 1.

Introduction It is explicitly noted here that the purpose of this fact sheet is to summarise previously developed concepts for the assessment of (i) inhalation exposure and (ii) inhalation absorption of metals and metal compounds under occupational exposure situations.

Relatively few lines of evidence might be needed to show significant potential for vapor intrusion to occur at levels of concern, prompting timely health protective recommendations and education. Conversely, more lines of evidence often are needed to confirm with reasonable certainty that there are no health Size: 1MB.

Exposure Factors Handbook Chapter 6—Inhalation Rates. Table Recommended Long-Term Exposure Values for Inhalation (males and females combined) Age Group. Mean (m. 3 /day) Sources Used for Means th. Percentile. b (m. 3 /day) Sources Used for th.

Percentiles Multiple Percentiles Birth to. Typically, exposure occurs by one of three exposure routes—inhalation, ingestion, or dermal. Inhalation exposure can result from breathing air that is contaminated with particulate matter (e.g., dust), vapors (e.g., volatile or semivolatile contaminants), or aerosols.

Vapor Intrusion Fundamentals Vapor Intrusion Fundamentals Dr. Blayne Hartman Hartman Environmental Geoscience [email protected] This training focuses on some of the basic principles that need to be understood in order to understand and effectively manage the vapor intrusion pathway.

The assessment of exposure to ethanol vapors released during ABHR for one day's work was given by the following formula: Q daily = Q sequence × α × γ × ν × Φ, with Q sequence being the quantity of ethanol vapor during the sequence (mg), α being the percentage absorbed by inhalation from the emission value (according to the literature Cited by: 7.

Fiserova-Bergerova V. () Modeling of Uptake and Clearance of Inhaled Vapors and Gases. In: Gut I., Cikrt M., Plaa G.L. (eds) Industrial and Environmental Xenobiotics. Proceedings in Cited by: 1. Thus, during inhalation exposures blood and airway tissue vapor concentrations increase to a steady state value and increase no further no matter how long the exposure.

High tissue concentrations can be obtained with highly soluble vapors, thus solubility, as measured by blood:air partition coefficient, is a fundamentally important physical Cited by:   Studies using animal modeling of chronic exposure to electronic cigarette vapors have shown potential adverse pulmonary effects, including signs of airspace enlargement and altered antimicrobial defense (Sussan et al.

; Garcia‐Arcos et al. ; Hwang J. et al. However, these phenomena were largely attributable to the nicotine Cited by: Described here is a novel inhalation exposure system developed to deliver a controlled inhaled dose of HD vapor through an endotracheal tube to a mid to large sized animal model to evaluate potential medical by: 3.

The latest edition of the Exposure Factors Handbook was released inbut since OctoberEPA has begun to release chapter updates individually. This new process allows risk assessors to get the latest information as new data becomes available.

To make it easier to find these chapter updates, the chapter date column has been added to Table 1. Initially, the pulmonary injury model was attempted using SM vapors and exposure by nose-only inhalation.

However, this exposure route yielded severe nasal damage with minimal lung injury. The high reactivity of SM, coupled with the large surface area of the rodent nasal passages, led to an apparent scrubbing of the by: Described here is a novel inhalation exposure system developed to deliver a controlled inhaled dose of HD vapor through an endotracheal tube to a mid to large sized animal model to evaluate potential medical countermeasures.

IHSTAT is an Excel application that calculates a variety of exposure statistics, performs goodness of fit tests, and graphs exposure data. Multiple languages are available. The book, “A Strategy for Assessing and Managing Occupational Exposures” is intended to accompany this tool as it provides critical detail on the use and interpretation.

It was a basic component of our qualitative exposure assessment process at both Celanese and later at OxyChem. We sent every exposure scenario through this qualitative process and predicted the likely exposure category (similar to AIHA’s except we had an extra category to times the OEL and then to time the OEL).

Journals & Books; Register Sign in. Bayesian estimation of variability in adipose tissue blood flow in man by physiologically based pharmacokinetic modeling of inhalation exposure to toluene. Author links open overlay panel Fredrik Jonsson a Gunnar Johanson a b.

A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke Author links open overlay panel Fawaz Alasmari a Laura E. Crotty Alexander b c Christopher A.

Drummond d Youssef Sari aCited by: 5. Our estimated inhalation exposure of benzene wasand μg/m³ for petrol pump workers, car drivers and environmentally exposed control. The Air Pollutants Exposure Model (APEX) is a PC-based model that was derived from the probabilistic NAAQS Exposure Model for carbon monoxide (pNEM/CO).

Reports describing prior OAQPS applications of the pNEM to carbon monoxide and ozone are available. APEX serves as the human inhalation exposure model within the Total Risk Integrated. The goal of the current study was to characterize inhalation dosimetric patterns of diacetyl and butyric acid, two components of BFV, and to develop a hybrid computational fluid dynamic-physiologically based pharmacokinetic model (CFD-PBPK) to describe these patterns.

Uptake of diacetyl and butyric acid vapors, alone and in combination, Cited by: Chronic E-CIG Vapor Exposure for 6 Months Decreased GABA in the FC.

The effects of 6 months inhalation of E-CIG vapors containing nicotine on the levels of GABA in the FC and STR were investigated. Chronic daily exposure to E-CIG vapor induced a significant decrease in the levels of GABA in the FC (p = ; Figures 5A, B) compared to air by: 3. Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text.

Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases.

Inhalation Toxicity of GF Vapor in Rats as a Function of Exposure Concentration and Duration and Its Potency Comparison to GB [J. Anthony, Mark V. Haley, James H. Manthei, Ruth A. Way, Dave C. Burnett] on *FREE* shipping on qualifying offers.

This is a EDGEWOOD CHEMICAL BIOLOGICAL CENTER ABERDEEN PROVING GROUND MD. Dose assessment of internal exposure 8 Methodologies developed by ICRP are applied. These methodologies have been developed in order to introduce radiation protection quantities (e.g., effective dose, committed dose) Dosimetric quantities that have been established in order to plan.

Assessment of Exposure to Alcohol Vapor from Alcohol-Based Hand Rubs Article (PDF Available) in International Journal of Environmental Research and Public Health 9(3) March with.

Since poor air quality affects human health in the short and long term, much research has been performed on indoor and outdoor aerosol exposure; however, there is a lack of specific data on the exposure and health risks of inhalable aerosols that contain bioaerosol in different environments of human life.

To investigate the potential exposure to inhalable aerosols (in the Author: Hyeon-Ju Oh, Yoohan Ma, Jongbok Kim. Mathematical exposure modeling is an indirect method of determining exposure, particularly for human exposure to environmental contaminants.

It is useful when direct measurement of pollutant concentration is not feasible because direct measurement sometimes requires skilled professionals and complex.

The inhalation exposure to gasoline vapors for a service station attendant employs these assumptions: • Air concentrations during attendant's working hours as given in Table • An average workday of 8 hours, 5 days/week, 50 weeks/year, 50 years/lifetime (API, ). Therefore, the present analysis focuses on vapor inhalation as the primary exposure route of concern.

Occupational and Epidemiologic Studies The most frequent symptoms reported in workers exposed to xylene are headache, fatigue, lassitude, irritability, nausea, anorexia, and flatulence (Gerarde ). A Toxicological Profile for Gasoline was released on September 6, This edition supersedes any Carroll Snyder, Director, Laboratory of Inhalation Carcinogenicity and Toxicology, New York University, A.J.

Lanza Laboratories, Tuxedo, New York Certain workers have a greater risk of exposure to gasoline vapors. These include service.

Inhalation of Aldehydes and Effects on Breathing EPA Grant Number: RC Subproject: this is subproject numberestablished and managed by the Center Director under grant R (EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).

The acute effects of hydrocarbons on the cardiovascular system following inhalation exposure are well known because of the historical use of hydrocarbons as anesthetics and their use as narcotics through intentional inhalation of solvent and propellant tion of hydrocarbons has the potential to induce cardiac arrhythmias that can result in death.

@article{osti_, title = {Comparison of realistic and idealized breathing patterns in computational models of airflow and vapor dosimetry in the rodent upper respiratory tract}, author = {Colby, Sean M.

and Kabilan, Senthil and Jacob, Richard E. and Kuprat, Andrew P. and Einstein, Daniel R. and Corley, Richard A.}, abstractNote = {Abstract Context: Computational. LIST OF TABLES TABLE TABLE TITLE PAGE Estimated Gasoline Vapor Emissions in Unit Risk Factor Summary Lifetime Exposure Estimates for Emission Sources Considered in Risk Analysis Physicochemical Characteristics of the Test Materi al Formulation of Unleaded Gasoline Inhalation Exposure Concentrations.

BALF protein content was elevated in the PG:VG-N (P = ) and PG:VG-N+F (P = ) groups only, compared with air-breathing mice (Fig. 2F), suggesting that exposure to nicotine through inhalation of e-cig vapor but not through CS exposure can increase BALF protein content at this time point; in this case, addition of flavor to the e-cig had Cited by: For toddler (based on an inhalation rate of 8 m3/24 hr and bw of 10 kg) and using an AEL in mg a.s./kg bw/d, if ≤1 ⋅ ⋅ AEL long −term mw vp then risk from inhalation exposure for the toddler is negligible, otherwise inhalation exposure should be included in the risk assessment.

If the inhalation risk for the toddler isFile Size: 48KB. ISBN: OCLC Number: Description: pages: illustrations ; 27 cm: Contents: Ch. 1. Inhalation risk assessment at the Environmental Protection Agency / John E.

Whalan, Gary L. Foureman and John J. Vandenberg --Ch. development and application of acute exposure guideline levels for hazardous substances / George M. .Guidance on Pesticides Exposure Assessment of Operators, Workers, Residents and Bystanders EFSA Journal 20YY;volume(issue):NNNN 4 BACKGROUND AS PROVIDED BY THE COMMISSION91 92 EFSA issued in a “Scientific Opinion on Preparation of a Guidance Document on Pesticide 93 Exposure Assessment for Workers, Operators, Bystanders and File Size: KB.board recommended an interim 8-hr time-weighted-average (TWA) permissible exposure limit (PEL) of mg/m 3 and a min short-term exposure limit (STEL) of 1, mg/m 3 for vapors from all three fuels.

Those interim exposure limits were based on the board's review of the manufacturers' technical documentation and the National Institute of Occupational Safety and .